Medical Physics Graduate Program Faculty

Gino Fallone

B. Gino Fallone, OMRI, PhD,
PPhys, FCCPM,
DABMP, DABR, FAAPM

Professor and Director, Division of Medical Physics,
Department of Oncology
Director, Dept. of Medical Physics, Cross Cancer Institute

BSc (Physics Honors: McGill-1974)
MSc (Physics: Montréal-1976)
PhD (Physics: McGill-1983)

Fellow: Canadian College of Physicists in Medicine
Diplomat: American Board of Medical Physics
Diplomat: American Board of Radiology
Professional Physicist: Canadian Association of Physicists
Fellow: American Association of Physicists in Medicine
Knight, Order of Merit, Italy (Cavaliere, Ordine al Merito della Repubblica Italiana) ...more

Jump to list of Peer Reviewed Publications

Research Interests

Integration of a Linac with an MRI System for Real-Time Image-Guided Radiotherpy.

Please see the Linac-MR.ca website.

Image-Guided Adaptive Radiotherapy (IGAR)

The main goal of the research program entitled "Image-guided adaptive radiotherapy (IGAR)" in CBIAR, is to achieve the maximum curing potential by precisely delivering a radiation dose distribution that is "sculpted" to the anatomical and biological extent of the tumor while delivering minimal dose to healthy tissue to reduce side effects.

The IGAR program incorporates one of the world's first human Helical TomoTherapy System, a ultra-high human whole body (3 T) MR Imaging and Spectroscopy System, an animal 9.4T MR Imaging and Spectroscopy System, an image-fusion laboratory, and the computer laboratories for the Canadian Computational Cancer Center (C4). The MR systems provide the anatomical, functional, metabolic and biochemical information to identify diseases at an earlier stage, and monitor treatment response immediately after and at intervals after treatment. The resultant information is integrated with PET images within our image fusion laboratories to design advanced adaptive radiation therapy delivered by the experimental TomoTherapy system. The C4 facilities will evaluate the clinical outcome with respect to treatment by imaging follow-up and by correlating with gene profiling information provided of PolyomX. This evaluation will allow the quantification of fundamental cancer processes and its varying treatment, in an effort to develop novel treatment strategies.

We deliver the dose by a Helical TomoTherapy system, a revolutionary treatment device that was funded by the CFI, ASRA and the ACF (Total of about $5M. Conventional modern CT and MR (1.5 T) do not show the full extent of the tumor. To obtain the full biological extent of the tumor and the healthy tissues (functional, biochemical information in addition to the anatomical information), we have received funds from the CFI and ASRIP (about $10 M) to install a ultra-high field MR system. The system comprises a 3 T MRI and MRS system ($4 M) from Philips which is far superior in imaging capabilities to conventional 1.5 T systems. In addition, we were able to acquire a 9.4 T (super high field) animal MRI and MRS system to perform studies in MR molecular imaging. The latter system brings us to the limit of what futuristic MR imaging and spectroscopy can do for cancer detection, and cancer therapy from radiation and from other cancer treatment agents. The acquisition of the latter system has been made possible with the partial financial $660K commitment from the ACF.

The IGAR facilities are unique in the world, and allow the delivery of advanced adaptive radiation treatments, offer functional and metabolic information of cancer, and quantify cancer processes, and make the Cross Cancer Institute the most advanced center in the world for cancer molecular imaging and adaptive radiation therapy.

Digital Electroradiography

The investigation of a high resolution non-contact voltage sensor to obtain latent images from xeroradiographic plates composed of amorphous Selenium (a-Se), resulting in the development of a digital radiographic system for on-line portal imaging. We are presently investigating the performance of a novel portal imaging device composed of metal/a-Se coupled to amorphous Silicon active flat-panels (thin film transistors).

Digital Portal Imaging and Automatic Image Registration and Verification

Our studies in the digital contrast enhancement of portal localization radiographs have resulted in improved visualization of the treatment area and adjacent regions, thus facilitating the task of accurate localization. Automatic registration of portal to reference images have been performed with morphological processing and correlation techniques. We have also implemented techniques to create megavoltage digital reconstructed radiographs (DRRs) of 3-D CT data to produce CT simulation of patient treatment and subsequent automatic registration to portal images. We are presently investigating the automatic registration of portal to DRRs in three dimensions for on-line verification of radiation treatment.

Inverse Treatment Planning

State-of-the art conformal therapy is a technique that achieves increased survival rate by using intensity modulated beams to deliver dose distributions that tailor a high-dose region to the tumor volume while the dose to the healthy tissue as low as possible. Optimizing techniques have developed to design the modulated beams through a process of inverse treatment planning (ITP). We have develop a novel ITP technique and now plan to incorporate clinically relevant objectives and constraints, and to incorporate emerging radiobiological information to design plans that maximizes tumor control with minimum complications.

Conformal Therapy

We are pursuing Image-Guided Adaptive Radiotherapy (IGAR) techniques that use advanced imaging modalities, conventional and ultra-high field MR, PET, CT, megavoltage CT, to deliver highly conformal therapy beams using a unique Helical TomoTherapy system within the Center for Biological Imaging and Adaptive Radiotherapy (CBIAR). Research in this avenue involves megavoltage CT, detector design and analysis, inverse planning, Monte Carlo simulation and dosimetry, radiobiological modeling, etc. Within the newly-created Canadian Computational Cancer Center, we provide through a computational and theoretical approach, the systematic simplification, quantification and visualization of cancer processes and conventional treatments into practical models that can be developed to significantly increase cure rates.

Selected Peer Reviewed Publications (since 2007):

A. Tessier,A. Yahya, M. Larocque, B.G. Fallone, A. Syme,
"Longitudinal Evaluation of the Metabolic Response of a Tumor Xenograft Model to Single Fraction Radiation Therapy Using Magnetic Resonance Spectroscopy",
Physics Medicine and Biology, PMB-100442, in press.

Arash Panahifar, Jacob L. Jaremko, Anthony G. Tessier, Robert G. Lambert, Walter P. Maksymowych, B. Gino Fallone, Michael R. Doschak,
"Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: Celecoxib may possess disease-modifying properties",
OAC1489, Osteoarthritis and Cartilage, in press.

E. Yip, J. Yun, K. Wachowicz, Z. Gabos, A. Heikal, S. Rathee, B.G. Fallone
"Prior Data Assisted Compressed Sensing: A Novel MR imaging strategy for real time tracking of lung tumors.
Medical Physics: 41 (8), 082301(12 pp), (2014).

D.L. Anderson, R. Mirzayans, B. Andrais, L.A. Siegbahn, B.G. Fallone, B. Warkentin,
"Spatial and temporal distribution of γH2AX fluorescence in human cell cultures following synchrotron-generated x-ray microbeams: Lack of correlation between persistent γH2AX foci and apoptosis",
J Synchrotron Radiation, 21(4), pp.801-810 (2014).

B. G. Fallone,
"The Rotating Biplanar-Magnetic Resonance Imaging System",
Seminars in Radiation Oncology, 24(3), pp.200-202 (2014). Invited

M.R. Paudel, M. Mackenzie, B.G. Fallone, S. Rathee,
"Clinical evaluation of normalized metal artifact reduction in kVCT using MVCT prior images (MVCT-NMAR) for radiotherapy treatment planning",
Int J Rad Onc Biol Phys, 89(3), pp.682-689 (2014).

A.M. Maunder, M. Daneshmand, B.G. Fallone, N. de Zanche,
"Experimental Verification of SNR and Parallel Imaging Improvements Using Composite Coil Arrays,
NMR in Biomedicine, # NBM-13-0208, in press.

R.L. Lagore, B.R. Roberts, C. Possanzini, C. Saylor, B.G. Fallone, N. DeZanche,
"A system for automated noise parameter measurements on MR preamplifiers and application to high B fields",
NMR Biomed May 29. doi: 10.1002/nbm.313, in press (2014)

A. Bingolbali, B.G. Fallone, A. Yahya,
"Comparison of Optimized Long Echo Time STEAM and PRESS Proton Magnetic Resonance Spectroscopy Lipid Olefinic Protons at 3 T",
J Magnetic Resonance Imaging, pmid 24338999 , Dec 12, doi;10.1002/jmri.245332 in press (2013).

A.M. Maunder, M. Daneshmand, P. Mousavi, B. G. Fallone, N. De Zanche,
"Stray capacitance between magnetic resonance imaging coil elements: Models and application to array decoupling,
IEEE Trans Trans Microwave Theory and Techniques, 61(12) , pp.4664-4677 (2013).

D. Anderson, B. Andrais, R. Mirzayans, E.A. Siegbahn , B.G. Fallone and B. Warkentin,
"Comparison of two methods for measuring γ-H2AX nuclear fluorescence as a marker of DNA damage in cultured human cells: applications for microbeam radiation therapy,
Journal of Instrumentation, 8(6), C06008- (2013).

M. Paudel, M. Mackenzie, B.G. Fallone, S. Rathee,
"Evaluation of normalized metal artifact reduction (NMAR) in kVCT using MVCT prior images for radiotherapy treatment planning",
Medical Physics, 40(8), 081701 (14 pp) (2013).

A. Heikal, K. Wachowicz, B.G. Fallone,
"MTF behaviour of compressed sensing MR spectroscopic imaging",
Medical Physics, 40(5), 052302 (10 pp) (2013).

J. Yun, K.Wachowicz, M. Mackenzie, S. Rathee, D. Robinson, B.G. Fallone,
"First Demonstration of Intrafractional MR Tumor Tracking using a linac-MR : A Phantom Study",
Medical Physics 40(5), 051718 (12 pp), (2013).

M. Reynolds, B.G. Fallone, S. Rathee,
"Dose Response of Selected Ion Chambers in Applied Homogeneous Transverse and Longitudinal Magnetic Fields",
Medical Physics, 40(4), 042102 (7 pp), (2013).

D. Baillie, J St.Aubin, B.G. Fallone, S. Steciw,
"Feasibility of producing a short, high energy S-band linear accelerator using a klystron power source",
Med. Phys. 40(4), 041713/5 (2013)

A. Troitskaia, B.G. Fallone, A. Yahya,
"Long Echo Time Proton Magnetic Resonance Spectroscopy for Estimating Relative Measures of Lipid Unsaturation at 3 T.."
Journal of Magnetic Resonance Imaging 37:944-949 (2013).

A. Keyvanloo, B. Burke, B. Warkentin, T. Tadic, S. Rathee, C. Kirkby, D.M. Santos, B.G. Fallone,
"Skin Dose in Longitudinal and Transverse Linac-MRIs using Monte-Carlo and realistic 3D MRI field models",
Medical Physics, 39(10), pp.6509-6521(2012).

M.R. Paudel, M.Mackenzie, B.G. Fallone, S. Rathee,
"Evaluation of metal artifacts in MVCT systems using a model based correction method",
Medical Physics, 39(10), pp. 6297-6308(2012).

B.Burke, K. Wachowicz, B.G. Fallone, S. Rathee,
"Effect of radiation induced current on the quality of MR images taken with an integrated linac-MR system",
Medical Physics, 39(10), pp. 6139-6147 (2012).

B. Burke, A. Ghila, B.G. Fallone, S. Rathee,
"Radiation induced current in the RF coils of integrated Linac-MR systems: the effect of buildup and magnetic field",
Medical Physics, 39(8), pp.5004-5014 (2012).

J.Yun, M. Mackenzie, S. Rathee, D. Robinson, B.G. Fallone,
"An artificial neural network (ANN) based lung tumor motion predictor for intra-fractional MR tumor tracking,
Medical Physics, 39(7), pp. 4423-4433 (2012).

D. Robinson, D. Liu, S. Steciw, C. Field, H. Daly, S. Kumar, G. Fallone, M. Parliament, J. Amanie,
"Prospective Study to Evaluate the Accuracy and Inter-User Variability of the Clarity 3-Dimensional Ultrasound System for Verification during External Beam Radiation Therapy for Clinically Localized Prostate Cancer"
Journal of Applied Clinical Medical Physics. 13(4), 100-112 (2012).

K. Wachowicz, T. Tadic, B.G. Fallone,
"Geometric distortion and shimming considerations in a rotating MR-linac design due to the influence of low-level external magnetic fields",
Medical Physics, 39(5), pp. 2659-2668(2012).

D. Anderson, E.A. Siegbahn, B.G. Fallone, R. Serduc, B. Warkentin,
"Evaluation of dose-volume metrics for microbeam radiation therapy dose distributions in head phantoms of various sizes using Monte Carlo simulations,"
Phys Med Bio 57(10), 3223-48 (2012).

J. Yun, E. Yip, K. Wachowicz, S. Rathee, M. Mackenzie, D. Robinson, B.G. Fallone,
"Evaluation of a lung tumor auto-contouring algorithm for intra-fractional tumor tracking using low-field MRI A phantom study",
Medical Physics, 39(3), pp. 1481-1494(2012).

D.M. Santos, J. St-Aubin, B.G. Fallone, S. Steciw,
"Magnetic shielding investigation for a 6 MV in-line linac within the parallel configuration of a linac-MR system"
Med. Phys. 39, 788-797 (2012).Front page of Issue
Selected for Virtual Journal of Biological Physics Research, Feb 1, 2012

T. Tadic and B.G. Fallone,
"Design and optimization of superconducting MRI magnet systems with magnetic materials",
IEEE Trans Applied Superconductivity, 22(2), pp.4400107-4400107 (2012).

A. Yahya, A. Tessier, B.G. Fallone,
"Effect of j-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T,"
Journal of Magnetic Resonance Imaging, 34, pp.1388-1396 (2011)

D. Bartusik, B. Tomanek, B. Blicharska, G. Fallone,
"Magnetic resonance assays of haloperidol in human serum albumin,"
Medicinal Chemistry Research, 20, pp. 62-66(2011).

J-D Jutras, B.G. Fallone, N.deZanche,
"Efficient multichannel coil data compression: a prospective study for distributed detection in wireless high-density arrays,"
Concepts Magn Reson Part B; MR Eng, 39B(2), pp. 64-77(2011).

D. Bartusik, B. Tomanek, G. Fallone,
"Monitoring of 3D breast carcinoma cell culture by proton magnetic resonance imaging,"
Medicinal Chemistry Research, 19, pp. 1153-1161(2011).

J. Moroz, J. Turner, C. Slupsky, B.G. Fallone, A. Syme,
"Tumor Xenograft Detection through Quantitative Analysis of the Metabolic Profile of Urine in Mice,"
Physics Medicine Biology, 56(3), pp. 5635-556 (2011). [Featured Article].

T. Tadic, B.G. Fallone,
"Design and optimization of a novel bored biplanar permanent magnet assembly for hybrid MRI systems,"
IEEE Trans Magnetics, 46(12), pp. 4052-4058 (2010).

T. Tadic, B.G. Fallone,
"Three-Dimensional Non-Axisymmetric Pole Piece Shape Optimization for Biplanar Permanent Magnet MRI Systems,"
IEEE Trans Magnetics, 4791), pp. 231-238 (2011).

R.Rivest, T. Riauka, A. Murtha, B.G. Fallone,
"Incorporation of planning contour data into avoxel based deformable registration algorithm for prostate adaptive radiation therapy,"
JACMP, in press,2010.

J. St-Aubin, S. Steciw, B.G. Fallone,
"Waveguide detuning caused by transverse magnetic fields on a simulated in-line 6 MV linac"
Med. Phys. 37(9), 4751-4754 (2010).

J. St-Aubin, S. Steciw, D.M. Santos, B.G. Fallone,
"Effect of longitudinal magnetic fields on a simulated in-line 6 MV linac"
Med. Phys. 37(9), 4916-4923 (2010).

J. St-Aubin, S. Steciw, B.G. Fallone,
"Magnetic decoupling of the linac in a low field biplanar linac-MR system"
Med. Phys. 37(9), 4755-4761 (2010).

J. St-Aubin, S. Steciw, B.G. Fallone,
"Effect of transverse magnetic fields on a simulated in-line 6 MV linac"
Physics in Medicine and Biology, 55(16), pp. 4861-4869 (Aug 21 2010).

C. Kirkby, B. Murray, S. Rathee, B.G. Fallone,
"Lung dosimetry in a linac-MR radiotherapy unit with a longitudinal magnetic field,"
Medical Physics,37(9) pp. 4722-4732 (2010).

M. Larocque, A. Syme, J. Allalunis-Turner, B.G. Fallone,
"ADC response to radiation therapy correlates with induced changes in radiosensitivity,"
Medical Physics, 37(7), pp. 3855-3861 (2010).

D. Bartusik, S. Tomanek, E. Lattova, H. Perreault, B.G. Fallone,
"Ex vivo assays of CEM cells cultured and treated in the three dimensional cultures,"
Biomedicine and Pharmacotherapy, 64, pp. 390-395 (2010).

M. Lamey, S. Rathee, L. Johnson, M. Carlone, E. Blosser, B.G. Fallone,
"Radiofrequency noise from the modulator of a linac,"
IEEE Trans Electromagnetic Compatibility, 52(3), pp. 530-538 (2010).

J. Yun, J. St-Aubin, S. Rathee, B.G. Fallone,
"Brushed permanent magnet DC MLC motor operation in an external magnetic field,"
Medical Physics, 37(5), pp. 2131-2134 (2010).

K. Wachowicz, T. Stanescu, B.G. Fallone,
"Implications of tissue magnetic susceptibility-related distortion on the rotating magnet in an MR-linac design,"
Medical Physics, 37(4), pp.1714-1721 (2010).

B.G. Fallone, R. Rivest, T. Riauka and A. Murtha,
"Assessment of a commercially available automatic deformable registration system,"
J Appl Clin Med Phys, 11(3), pp. 101-123 (2010).

P.Stavrev, C. Schinkel, N. Stavreva, B. Warkentin, M. Carlone, B.G. Fallone,
"Population TCP estimators in case of heterogeneous irradiation: A new discussion of an old problem,"
Act Oncol, 49(8), pp. 1293-1303 (2010).

J. St-Aubin, S. Steciw, B.G. Fallone,
"An integrated 6 MV linear accelerator model from electron gun to dose in a water tank,"
Medical Physics, 37(5), pp. 2279-2288 (2010).

A. Yahya, B.G. Fallone,
"T2 determination of the j-coupled methyl protons of lipids: in-vivo illustration with tibial bone marrow at 3 T,"
Journal of Magnetic Resonance Imaging, 31, pp. 1514-1521 (2010).

M. Lamey, J. Yun, B. Burke, S. Rathee, B.G. Fallone,
"Radiofrequency noise from an MLC: a feasibility study of the use of MLCs for linac-MR systems,"
Phys. Med. Biol., 55(4), pp..981-994 (2010).

M. Lamey, B. Burke, E. Blosser, S. Rathee, N. DeZanche, B.G. Fallone,
"Radiofrequency shielding for a linac-MRI system,"
Phys. Med. Biol., 55(4), pp. 995-1006(2010).
[Editor’s Choice]

B. Burke, B.G. Fallone, S. Rathee,
"Radiation induced currents in MR I- RF coils: application to linac-MR integration,"
Phys Med Biol, 55(3), pp. 735-746 (2010).

M. Larocque, A. Syme, A. Yahya, K. Wachowicz, J. Allalunis-Turner and B.G. Fallone,
"Monitoring T2 and ADC at 9.4 T following fractionated external beam radiation therapy in a mouse model,"
Phys Med Biol, 55(5), pp. 1381-1391 (2010).

J. St-Aubin, S. Steciw, B.G. Fallone,
"The design and tuning of a simulated in-line side-coupled 6 MV linear accelerator waveguide,"
Medical Physics, 37(2), pp. 466-476 (2010).
[selected for Virtual Journal of Biological Physics Research, Jan. 15 , 2010]

D. Bartusik, B. Tomanek, E. Lattova, H. Perreault, G. Fallone,
"Combined treatment of human MCF-7 breast carcinoma with antibody, cationiclipid and hyaluronic acid using ex-vivo assays,"
J. Pharm. Biomed. Anal , 51(1), pp. 192-201 (2010)

N. Pervez, C. Small, M. MacKenzie, D. Yee, M. Parliament, S. Ghosh, A. Mihai, J. Amanie, C. Field, D. Murray, G. Fallone, R. Pearcey,
"Acute toxicity in high risk prostate cancer patients treated with androgen suppression and hypofractionated intensity modulated (IMRT),"
Int. Journal of Rad Oncol Biol Phys,76(1), pp. 57-64 (2010).

P. Kirvan, T. Monajemi, B.G. Fallone, S. Rathee,
"Performance Characterization of a MVCT Scanner using Multi-Slice Thick, Segmented Cadmium Tungstate-Photodiode Detectors,"
Medical Physics, 37(1), pp. 249-257 (2010).

T. Stanescu, H. Jans, K .Wachowicz, B.G. Fallone,
"Investigation of a 3D system distortion correction method for MR images,"
J Appl Clin Med Phys, 11(1), pp. 200-216 (2010).

D. Bartusik, B. Tomanek, E. Lattova, H. Perreault, J. Tuszynski, B.G. Fallone,
"Derivatives of thiocolchicine and its applications to CEM cells treatment using (19)F Magnetic Resonance ex vivo,"
Bioorg Chem., 38(1), pp.1-6 (2010).

K. Joseph, A. Syme, C. Small, H. Warkentin, H. Quon, S. Ghosh, C. Field, N. Pervez, K. Tankel, S. Patel, N. Usmani, D. Severin, T. Nijjar, B.G. Fallone, J. Pedersen,
"A treatment planning study comparing helical tomotherapy with IMRT for treatment of anal cancer,"
Radiother Oncol, 94(1), pp. 60-66 (2010).

R.C. Rivest, T.A. Riauka, A.D. Murtha, B.G. Fallone,
"Dosimetric implications of two registration based patient positioning methods in prostate image guided radiation therapy (IGRT),"
Radiology and Oncology, 43(3), pp. 203-212 (2009). [doi:10.2478/v10019-009-0030-z]

S. Thomas, K. Wachowicz, B.G. Fallone,
"MRI of Prostate Brachytherapy Seeds at High Field: a Phantom Study,"
Medical Physics, 36(11), pp. 5228-5234 (2009).

R.C. Rivest, T. Riauka, A.D. Murtha, B.G. Fallone,
"Prostate positioning errors associated with two automatic registration based image guidance strategies,"
J Appl Clin Med Phys, 10(4), pp.165-175 (2009).

D. Bartusik, B. Tomanek, E. Lattova, H. Perreault, J. Tuszynski, B.G. Fallone,
"The efficacy of new colchicine derivatives and viability of the T-Lymphoblastoid cells in three-dimensional culture using (19)F MRI and HPLC-UV ex vivo."
Bioorg . Chem, 37(6) pp. 193-201 (2009).

P. Stavrev, C. Schinkel, N. Stavreva, B.G. Fallone,
"How well are clinical gross tumor volume (DVHs) approximated by an analytical function?"
Radiol Oncol 43(2), pp. 132-135 (2009).

A. Syme. C. Kirkby, R. Mirzayans, M. Mackenzie, C. Field, B.G. Fallone,
"Relative biological damage and electron fluence in and out of a 6 MV photon field,"
Phys. Med. Biol. 54(12), pp. 6623-6633 (2009).

M.A. Mackenzie, Y. Zhao, C. Kirkby, B.G. Fallone,
"Monte Carlo evaluation of the convolution/superposition algorithm of Hi-Art tomotherapy in heterogeneous phantoms and clinical cases,"
Med. Phys. 36 (8), pp. 3856-3857 (2009).

N. Stavreva, P. Stavrev, B.G. Fallone,
"Probability dynamics of a repopulating tumor in case of fractionated external radiotherapy,"
Physica Medica, 25(4), pp.181-191 (2009).

L.N. Baldwin, K. Wachowicz, B.G. Fallone,
"A two step scheme for distortion rectification of magnetic resonance images,"
Medical Physics 36(9), pp. 3917-3926 (2009).
[selected for cover of the Journal, and selected for cover of 2011 Media Kit for Medical Physics].

M. Larocque, A. Syme, A.Yahya, K. Wachowicz, J. Allalunis-Turner, B.G. Fallone,
"Temporal and dose dependence of T2 and ADC at 9.4 T in a mouse model following single fraction radiation therapy,"
Medical Physics, 36(7), pp. 2948-2954 (2009).

B.G. Fallone, B. Murray, S. Rathee, T. Stanescu, S. Steciw, S. Vidakovic, E. Blosser and D. Tymofichuk,
"First MR images obtained during megavoltage photon irradiation from a prototype linac-MR system."
Med. Phys. 36, 2084-2088(2009).
[Awarded the Sylvia Fedoruk Prize for Medical Physics].

B. Burke, M. Lamey, S. Rathee, B. Murray and B.G. Fallone,
"Radio Frequency noise from clinical linear accelerators."
Phys. Med. Biol. 54(April), 2483-2492(2009).

N.Stavreva, P. Stavrev, B.G. Fallone,
"Confidence limits of the probability of success in animal experiments and clinical studies: a Bayesian approach,"
Physica Medica, 25, pp.43-46 (2009).

D. Bartusik, B. Tomanek, D. Siluk, R. Kaliszan, B.G. Fallone,
"The application of 19F magnetic resonance ex vivo imaging of three-dimensional cultured breast cancer cells to study the effect of δ- tocopherol,"
Analytical Biochemistry, 387, pp.315-317 (2009).

C. Kirkby, T. Stanescu, B.G. Fallone,
"Magnetic field effects on the energy deposition spectra of MV photon radiation,"
Phys Med Biol, 54(2), 243-257 (2009).

A. Yahya, B.G. Fallone,
"Detection of glutamate and glutamine (Glx) by turbo spectroscopic imaging,"
J Magnetic Resonance, 196, pp. 170-177(2009).

A.A. Heikal, K. Wachowicz, Steven D. Thomas, B.G. Fallone,
"A phantom to assess the accuracy of tumor delineation using MRSI,"
Radiol Oncol 42(4), pp. 232-239 (2008). [doi:10.2478/v10019-008-0015-3]

Y.Zhao, M. Mackenzie, C. Kirkby, B.G. Fallone,
"Monte Carlo evaluation of a treatment planning system for helical tomotherapy in an anthropomorphic heterogeneous phantom and for clinical treatment plans,"
Med Phys, 35(12), pp. 5366-5374 (2008).

D .Yee, R. Pearcey, G. Dundas, J. Hanson, M. Mackenzie, D. Robinson, C. Field, L.Underwood, R. Urtasun, N. Pervez, B.G. Fallone,
"Dosimetric comparison of tomotehrapy versus 4-4 field pelvic box altered fractionation radiotherapy treatment plans for invasive squamous cell carcinoma,"
Cancer Therapy, 6, pp. 553-562 (2008).

T. Stanescu, J-S Jans, N. Pervez, B.G. Fallone,
"A study on the MRI-based radiation treatment planning of intracranial lesions,"
Phys Med Biol, 53(13), 3579-3593 (2008).

Y. Zhao, C. Kirkby, M. Mackenzie, B.G. Fallone,
"Monte Carlo calculation of helical tomotherapy dose delivery,"
Med Phys, 35(8), pp. 3491-3500 (2008).

C. Kirkby, T. Stanescu, S. Rathee, M. Carlone, B. Murray and B.G. Fallone,
"Patient dosimetry for hybrid MRI-radiotherapy systems."
Med. Phys. 35, 1019-1027 (2008).

A. Yahya, B. Maedler, B.G.Fallone,
"Exploiting the Chemical Shift Displacement Effect in the Detection of Glutamate and Glutamine (Glx) with PRESS,"
J.Magn. Reson, 191, pp. 120-127 (2008). [doi:10.1016/j.jmr.2007.12.007]

E.P. Saibishkumar, M. Mackenzie, D. Severin, A. Mihai, J. Hanson, H. Daly, B.G. Fallone, M. Parliament, B. Abdulkarim,
"Skin-Sparing Radiation using Intensity-Modulated Radiotherapy After Conservative Surgery in Early-Stage Breast Cancer: A Planning Study,"
Int J Radiat Oncol Biol Phys, 70(2), pp.485-91 (2008). 0360-3016 (Print), Doi:10.1016/j.ijrobp_2007.06.049

E.P. Saibishkumar, M. Parliament, N. Jha, M. Mackenzie, R. Scrimger, C. Field, B.G. Fallone,
"Sparing the parotid glands and surgically transferred submandibular gland with helical tomotherapy in post-operative radiation of head and neck cancer: A planning study,"
Radiotherapy and Oncology, 85, pp. 98-104 (2007).

C. Schinkel, M. Carlone, B. Warkentin and B.G. Fallone,
"An analytic investigation into the effect of population heterogeneity on parameter ratio estimates."
Int J Radiat Oncol Biol Phys. 2007 Nov;69(4):1323-30

C. Schinkel, N. Stavreva, P. Stavrev, M. Carlone and B.G. Fallone,
"Functional form comparison between the population and the individual Poisson based TCP models."
Radiol. Oncol. 41(2), pp. 90-98 (2007).

A. Yahya and B.G. Fallone,
"Incorporating homonuclear polarization transfer into PRESS for proton spectral editing: Illustration with lactate and glutathione."
J.Magn. Reson., pp.111-121 (2007), doi:10.1016/j.jmr.2007.06.009.

P. Stavrev, C. Schinkel, N. Stavreva, K. Markov and B.G. Fallone,
"Analytical investigation of properties of the iso-NTCP envelope."
Radiol. Oncol. 41(1), pp. 41-47 (2007).

C. Kirkby, C. Field, M. MacKenzie, A. Syme and B.G. Fallone,
"A Monte Carlo study of the variation of electron fluence in water from a 6 MV photon beam outside of the field."
Phys. Med. Biol. 52, pp. 3563-3578 (2007).

D.M. Drabik, M. Mackenzie, and B.G. Fallone,
"Quantifying appropriate PTV setup margins: analysis of patient setup fidelity and intrafraction motion using post treatment MVCT scans (TomoTherapy)."
Int J Radiat Oncol Bio Phys, 68(4), pp. 1222-1228 (2007).

K. Breitman, S. Rathee, C. Newcomb, B. Murray, D. Robinson, C. Field, H. Warkentin, S. Connors, M. MacKenzie, P. Dunscombe and B.G. Fallone,
"Experimental Validation of the Eclipse AAA Algorithm."
J. App. Clin. Med. Phys, 8(2), pp.76-92, Spring (2007).

L.N. Baldwin, K. Wachowicz , S.D. Thomas , R. Rivest and B.G. Fallone, "Towards MR-based Treatment Planning: Characterisation of Geometric Distortion in 3 T MR Images."
Med Phys. 34(2), pp. 388-399 (2007).

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