Medical Physics Faculty

Research Interests

Molecular magnetic resonance imaging (MRI) of cancer, multimodal imaging, RF coils for MRI, functional MRI, image guided therapy, new medical technologies.

Selected Publications

(Total: 7 book chapters and 120 publications, over 100 oral presentations and over 200 conference abstracts)

Sboto-Frankenstein UN, Tiffany Lazar T, Bolster RB, Thind S, Patricia Dreessen de Gervai P, Gruwel MHL, Smith SD, Tomanek B,
"Symmetry of the Fornix Using Diffusion Tensor Imaging",
JMRI 40(4):929-36, 2014.

Lama S, Auer RN, Tyson R, Gallagher CN, Tomanek B, Sutherland GR,
"Lactate Storm Marks Cerebral Metabolism following Brain Trauma",
J. Biol. Chem 289(29):, 2014.

Piedzia W, Jasinski K, Kalita K, Tomanek B, Weglarz W,
"White and gray matter contrast enhancement in MR images of the mouse brain in vivo using IR UTE with a cryo-coil at 9.4 T.",
J Neurosc Meth 232:30–35, 2014.

Couch MJ, Blasiak B, Tomanek B, Ouriadov AV, Fox MS, Dowhos KM, Albert MS,
"Hyperpolarized MRI Agents and Inert Gas MRI: The Future",
Molecular Imaging and Biology (published online Sept 17, 2014).

Kulinowski P, Mlynarczyk A, Jasinski K, Tomanek B, Talik P, Gruwel M, Weglarz W, Dorozynski P,
"Magnetic Resonance Microscopy for Assessment of Morphological Changes in Hydrating Hydroxypropylmethylcellulose Matrix Tablets in situ - is it Possible to Detect Phenomena Related to Drug Dissolution Within the Hydrated Matrices?"
Pharmaceutical Research, 31(9):2383-92, Sept 2014.

de Gervai P, Sboto-Frankenstein UN, Bolster RB, Thind S,
Gruwel MLH, Smith SD, Tomanek B,
"Tractography of Meyer's Loop asymmetries",
Epilepsy Research, 108:872-882, 2014.

Blasiak B, Landry J, Tyson R, Sharp J, Iqbal U, Abulrob A, Rushford D,
Matyas J, Ponjevic D, Sutherland GR, Wolfsberger S, Tomanek B,
"Molecular susceptibility weighted imaging of the glioma rim in a mouse model",
J Neurosc Meth 226:132-138, 2014.

Sharp JC, King SB, Deng Q, Volotovskyy V, Tomanek B,
"High-resolution MRI encoding using radiofrequency phase gradients",
NMR Biomed, 26(11):1602-7, 2013.

Simard B, Tomanek B, van Veggel F, Abulrob A,
"Optimal dye-quencher pairs for the design of an 'activeatable' nanoprobe for optical imaging",
Photochem. Photobiol. Sci., 12(10):1824, 2013.

Kornelsen J, Smith S, McIver T, Sboto-Frankenstein U, Latta P, Tomanek B,
"Functional MRI of the thoracic spinal cord during vibration sensation",
JMRI, 37(4): 981-985, 2013.

Blasiak B, Tomanek B, Van Veggel FCJM,
"Applications of nanoparticles for MRI cancer diagnosis and therapy",
J Nanomaterials, 2013:1-12, 2013.

Sharp J, King SB, Deng Q, Volotovskyy V, Tomanek B,
"A cheaper, quieter MRI system",
Nature, 501:138-9, Sept 12, 2013.

Blasiak B, Barnes S, Foniok T, Rushforth D, Matyas J, Ponjevic D, Weglarz WP, Tyson R, Iqbal U, Abulrob A, Sutherland GR, Obenaus A, Tomanek B,
"Comparison of T2 and T2*-weighted MR molecular imaging of a mouse model of glioma",
BMC Medical Imaging, 13:20-28, 2013.

Zhu X, Sharp J, Tomanek B,
"A Pixel is an Artifact: On the Necessity of Zero-filling in Fourier Imaging",
Concepts in Magnetic Resonance Part A. 42(2): 32-44, 2013.

Kornelsen J, Sboto-Frankenstein UN, McIver T, Gervai P, Wacnik P,
Berrington N, Tomanek B.
"Default mode network functional connectivity altered in failed back surgery syndrome",
Journal of Pain, 14 (5):483-491, 2013.

Burda Z, Kornelsen J, Nowak MA, Porebski B, Sboto-Frankenstein U,
Tomanek B, Tyburczyk J,
"Collective correlations of brodmann areas fMRI study with RMT-denoising",
Acta Physica Polonica B, 44(6):1243-59, 2013.

Deng Q, King SB, Volotovskyy V, Tomanek B, Sharp JC,
"B1 Transmit Phase Gradient Coil for Single-Axis TRASE RF Encoding",
Magnetic Resonance Imaging , 31(6):891-899, 2013.

Bartusik D, Tomanek B,
"Detection of 19F-Labeled Biopharmaceuticals in Cell Cultures with Magnetic Resonance",
Advanced Drug Delivery Reviews, 65(8):1056-64, 2013.

King AJ, Deng Q, Tyson R, Sharp JC, Matwiy J, Tomanek B, Dunn JF,
"In Vivo Open-Bore MRI Reveals Region- and Sub-Arc-Specific Lengthening of the Unloaded Human Posterior Cruciate Ligament",
PLoS ONE 7(11), 2012.

Sarty GE, Sharp J, Tomanek B, Turek K, Obenaus A, Scott A, Piche L, Kontulainen S, Chilibeck P, Farthing J, Baxter-Jones A, Pierson RA,
"A magnetic resonance imager for the international space station",
Proc. Int Astronautical Congress, 1:217-223; 2012.

Kulinowski P, Mlynarczyk A, Dorozynski P, Jasinski K, Gruwel MLH,
Tomanek B, Weglarz WP,
"Magnetic Resonance Microscopy for Assessment of Morphological Changes in Hydrating Hydroxypropylmethyl Cellulose Matrix Tablets in situ",
Pharmaceutical Research, 29(12):3420--3433, 2012.

Mert A, Wolfsberger S, Bühler K, Sutherland G, Tomanek B,
Widhalm G, Kasprian G, Knosp E,
"Brain Tumor Surgery with 3-dimensional Surface Navigation",
Neurosurgery, 71(2):287-95, 2012.

Tomanek B, Iqbal U, Blasiak B, Abulrob A, Albaghdadi H, Matyas JR,
Ponjevic D, Sutherland GR,
"Evaluation of Brain Tumor Vessels Specific Contrast Agents for Glioblastoma Imaging",
Neuro-Oncology, 14(1):53-63, 2012. doi: 10.1093/neuonc/ nor183.

Widhalm G, Minchev G, Woehrer A, Preusser M, Kiesel B, Furtner J, Mert A, Di Ieva A, Tomanek B, Prayer D, Marosi C, Hainfellner JA, Knosp E, Wolfsberger S,
"Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies",
Neurosurg Rev. Jul;35(3):381-91, 2012.

Das GK, Johnson NJJ., Cramen J, Blasiak B, Latta P, Tomanek B, van Veggel FCJM,
"NaDyF4 Nanoparticle as T2 Contrast Agent for Ultra-High Field Magnetic Resonance Imaging",
J. Phys. Chem. Lett. 2012, 3:524-529. DOI: 10.1021/jz201664h

Dong C, Korinek A, Blasiak B, Tomanek B, van Veggel F,
"Cation exchange: a facile method to make NaYF4:Yb,Tm-NaGdF4 core-shell nanoparticles with a thin, tunable, and uniform shell",
Chemistry of Materials. 24(7):1297–1305, 2012.

Jasinski K, Mlynarczyk A, Latta P, Volotovskyy V, Weglarz W, Tomanek B,
"A Volume Microstrip RF Coil for MRI Microscopy",
Mag Reson Imag. 30(1):70-77, 2012.

Blasiak B, Foniok T, Deng C, Tomanek B,
"A comparison of MR imaging of a mouse model of glioma at 0.2T and 9.4T",
J Neurosc Meth, 240:118-123, 2012.

Bartusik D and Tomanek B,
"Detection of trastuzumab efficacy using 1H MRI ex vivo of breast cancer cells",
Medicinal Chemistry Research, 21(9): 2316-19, 2012.

Lattová E, Bartusik D, Spicer V, Jellusova J, Perreault H, Tomanek B,
"Alterations in Glycopeptides Associated with Herceptin Treatment of Human Breast Carcinoma MCF-7 and T-Lymphoblastoid Cells",
Molecular and Cellular Proteomics, Sep;10(9):M111.007765, 2011.

Latta P, Gruwel MLH, Debergue P, Sboto-Frankenstein U, Tomanek B,
"Convertible pneumatic actuator for magnetic resonance elastography of the brain",
Magn Reson Imag 29(1):147-52, 2011.

Bartusik D, Tomanek B, Blicharska B and Fallone G,
"Magnetic resonance assays of haloperidol in human serum albumin",
Medicinal Chemistry Research, 20(1):62-66, 2011.

Gruwel MHL, Latta P, Tomanek B,
"Improvements in MR imaging of solids through gradient waveform optimization",
Can J Chem (Wasylishen special issue), 89:729-736, 2011.

Lin HY, Freed D, Lee TWR, MD, Arora CR, Ali A, Almoustadi W, Xiang B,
Wang F, Large S, King SB, Tomanek B, Tian G.
"Quantitative Assessment of Cardiac Output and Left Ventricular Function by Noninvasive Phase-Contrast and Cine MRI: Validation Study With Invasive Pressure-Volume Loop Analysis in a Swine Model",
J Magn Reson Imag, 34:203-210, 2011.

Blasiak B, Zhang Z, Zhang X, Foniok T, Sutherland GR, Veres T, Tomanek B.
"The effect of coating of Fe3O4/silica core/shell nanoparticles on T2 relaxation time at 9.4T",
Eur J App Phys Nanotech, 55:10401, 2011.

Gruwel MLH, Latta P, Matwiy B, Sboto-Frankenstein U, Gervai P, Tomanek B.
"Measurement of Viscoelastic Properties of Condensed Matter using Magnetic Resonance Elastography",
Measurement Science Review, 10(5):1-6, 2010.

Gruwel MLH, Latta P, Matwiy B, Tomanek B.
"Characterization of food stuffs using Magnetic Resonance Elastography",
Food Research Int, 43:2087-2092, 2010.

Bartusik D, Tomanek B, Siluk D, Kaliszan R.
"19F MRI and 3D CEM cells to study the effects of tocopherols and tocotrienols",
J Pharmac Biomed Analysis, 53(3):599-602, 2010.

Iqbal U, Trojahn U, Albaghdadi H, Zhang J, O Connor-McCourt M,
Stanimirovic D, Tomanek B, Sutherland G.
"Kinetic Analysis of Novel Mono- and Multivalent VHH-Fragments and their Application for Molecular Imaging of Brain Tumors",
British Journal of Pharmacology, 160(4):1016-28, 2010.

Blasiak B, Tomanek B, Abulrob A, Iqbal U, Stanimirovic D,
Albaghdadi H, Foniok T, Lun X, Forsyth P, Sutherland GR.
"Detection of T2 changes in an early mouse brain tumor",
Magn Res Imag, 28:784-789, 2010.

Lattova E, Tomanek B, Bartusik D, Perreault H,
"N-glycomic changes in Human Breast Carcinoma MCF-7 and T-Lymphoblastoid Cells after Treatment with Herceptin and Herceptin/Lipoplex",
Journal of Proteome Research 9(3):1533-40, 2010.

Onu M., Gervai P, Cohen-Adad J, Lawrence J, Kornelsen J,
Tomanek B, and Sboto-Frankenstein UN.
"Human Cervical Spinal Cord Funiculi: Investigation with Magnetic Resonance Diffusion Tensor Imaging",
J Magn Reson Imaging 31:829-37, 2010.

Bartusik D, Tomanek B and Fallone G,
"Monitoring of 3D breast carcinoma cell culture using proton magnetic resonance",
Medicinal Chemistry Research 9(19):1153-61, 2010, DOI 10.1007/s00044-009-9259-8

Latta P, Gruwel MLH, Jellúš V, Tomanek B,
"Bloch simulations with intra-voxel spin dephasing",
J Magn Res 203(1):44-51, 2010.

Bartusik D, Tomanek B,
"Application of 19F magnetic resonance to study the efficacy of fluorine labeled drugs in the three-dimensional cultured breast cancer cells",
Archives of Biochemistry and Biophysics, 493:234–241, 2010.

Bartusik D, Tomanek B, Lattová E, Perreault H, Tuszynski J, Fallone G,
"Derivatives of thiocolchicine and its applications to CEM cells treatment using 19F Magnetic Resonance ex vivo",
Bioorganic Chemistry 38:1–6, 2010.

Bartusik D, Tomanek B,
"Detection of fluorine labeled Herceptin using cellular 19F MRI ex vivo",
J of Pharmaceutical and Biomedical Analysis, 51:894-900, 2010.

Bartusik D, Tomanek B, Lattová E, Perreault H, Fallone G.
"Combined treatment of human MCF-7 breast carcinoma with antibody, cationic lipid and hyaluronic acid using ex vivo assays",
J Pharmaceutical and Biomedical Analysis 51:192–201, 2010.

Labak M, Foniok T, Kirk D, Rushforth D, Tkac I, Tomanek B,
Jasinski A, Grieb P,
"Metabolic changes in rat brain following intracerebroventrucular injections of streptozotocin: a new model of sporadic Alzheimer’s Disease",
Acta Neurochirurgica, Suppl.106:177-81, 2010.

Bartusik D, Tomanek B, Lattova E, Perreault H, Fallone G,
"Ex vivo assays of CEM cell cultured and treated in the three dimensional cultures",
Biomed and Pharmacotherapy, 64(6):390-395, 2010.

Zhang Z, Clime L, Tomanek B, Sutherland G, Veres T,
"Low temperature first order reversal curves and interaction effects on assembles of iron oxide nanoparticles",
Physica B: Condensed Matter. 404 (20):3666-3670, 2009. doi:10.1016/j.physb.2009.06.056.

Wang J, Liu H, Salerno TA, Tomanek B, Summers R,
Deslauriers R, Arora R, and Tian G,
"Alternate antegrade/retrograde perfusion: an effective technique to preserve hypertrophied hearts during valvular surgery",
European Journal of Cardio-thoracic Surgery, 35(1):69-76, 2009.

Sharp JC, Yin D, Bernhardt RH, Deng Q, Procca AE, Tyson RL ,Lo K, Tomanek B,
"The integration of real and virtual magnetic resonance imaging experiments in a single instrument",
Review of Scientific Instruments 80:093709-09, 2009.

Bartusik D, Tomanek B, Lattová E, Perreault H, Tuszynski J, Fallone G,
"The efficacy of new colchicine derivatives and viability of the T-Lymphoblastoid cells in three-dimensional culture using 19F MRI and HPLC-UV ex vivo",
Bioorganic Chemistry, 37:193-201, 2009.

Blasiak B, Volotovskyy V, Deng C, Tomanek B,
"An optimized solenoidal head radiofrequency coil for low-field magnetic resonance imaging",
Magnetic Resonance Imaging 27:1302-1308, 2009. DOI: 10.1016/j.mri.2009.05.018.

Jin AY, Tuor UI, Rushforth D, Filfil R, Kaur J, Ni F, Tomanek B, Barber PA,
"Magnetic resonance molecular imaging of post-stroke neuroinflamation with a P-selectin targeted iron oxide nanoparticle",
Contrast Media Mol Imaging 4:1-7, 2009, DOI: 10.1002/cmmi.292.

Bartusik D, Tomanek B, Siluk D, Kaliszan R, Fallone G,
"The application of 19F Magnetic Resonance ex vivo Imaging of 3D cultured breast cancer cells to study the effect of δ-tocopherol",
Anal. Biochem. 387:315-317, 2009.

Węglarz WP, Tanasiewicz MM, Gruwel MLH, Tomanek B,
"MRI visualization of moisture ingress into porous tissue of decayed teeth",
Diffusion Fundamentals, 10:29(1), 2009.

Wang L, Deng J, Tian W, Xiang B, Yang T, Li G, Wang J, Gruwel M, Kashour T,
Rendell J, Glogowski M, Tomanek B, Freed D, Deslauriers R, Arora RC, and Tian G,
"Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts",
American Journal of Physiology: Heart and Circulation Physiology 297:H1020-H1031, 2009.

Wang L, Deng J, Wang J, Xiang B, Yang T, Gruwel M, Kashourc T, Tomanek B,
Summer R, Freed D, Jassal DS, Daid G, Glogowski M, Deslauriers R, Arora R, Tian G,
"Superparamagnetic iron oxide does not affect the viability and function of adipose-derived stem cells, and superparamagnetic iron oxide–enhanced magnetic resonance imaging identifies viable cells",
Magn Reson Imag, 27(1):109-119, 2009.

Tuor UI, Meng S, Qiao M, Webster N, Crowley S, Dyck RH, Tomanek B,
"Differential Progression of Magnetization Transfer Imaging Changes Depending on Severity of Cerebral Hypoxic-Ischemic Injury",
J Cereb Blood Flow Metab. 28:1613-23, 2008.

Volotovskyy V, Gruwel M, Lu H, Blasiak B, Tomanek B,
"A Multi Frequency Narrow Band Pass Filter",
Concepts in Mag Res Imag Part B, (MR Engineering), 33B(3):141-145, 2008.

Wang J, Liu HY, Lu H, Xiang B, Gruwel M, Tomanek B;
Deslauriers R, Tian GH,
"Identification of chronic myocardial infarction with extracellular or intravascular contrast agents in magnetic resonance imaging",
Acta Pharmacol-Sin. 29(1): 65-73, 2008.

Latta P, Gruwel M, Volotovskyy V, Weber MH, Tomanek B,
"Single-point imaging with a variable phase encoding interval",
Magn. Reson. Imag. 26 (1):109-116, 2008.

Wang J, Liu H, Salerno TA, Xiang B, Li G, Gruwel G,
Jackson M, Manley D, Tomanek B, Deslauriers R, Tian G,
"Does Normothermic Normokalemic Simultaneous Antegrade/Retrograde Perfusion Improve Myocardial Oxygenation and Energy Metabolism for Hypertrophied Hearts?"
The Annals of Thoracic Surgery, 83:1751 - 1759, 2007.

Gruwel MLH, Latta P, Tanasiewicz M, Volotovskyy V, Sramek M, Tomanek B,
"MR Imaging of teeth using a silent Single Point Imaging technique",
Appl. Phys. A. 88, 763:2007.

Latta P, Gruwel MHL, Volotovskyy V, Weber M, Tomanek B,
"Simple phase method for measurement of magnetic field gradient waveforms",
Mag Res Imag, 25:1272-1276, 2007.

Majcher K, Tomanek B, Tuor UI, Jasiński A, Foniok T, Rushforth D, Hess G,
"Functional Magnetic Resonance Imaging within the Rat Spinal Cord Following Peripheral Nerve Injury",
NeuroImage 38(4):669-676, Dec. 2007.

Qiao M, Rushforth D, Wang R, Shaw RA, Tomanek B, Dunn J, Tuor UI,
"BOLD MR Signal and Cerebral Oxygenation Responses to Brain Activation are Enhanced by Concurrent Transient Hypertension in Rats",
J. Cereb. Blood Flow and Metab 27:1280-1289, 2007.

Jin A, Rushforth D, Filfil R, Kaur J, Tuor U, Foniok T, Deka K, Kirk D,
Lee-Petersen J, Tomanek B, Ni F, Barber P,
"Magnetic Resonance Molecular Imaging of Activated Endothelium in Acute Stroke Using a Targeted Iron-Oxide Nanoparticle Contrast agent",
J of Cerebr Blood Flow and Metab 27:BP17-01W, 2007.

Tomanek B, Foniok T, Saunders J, Sutherland G,
"An Integrated RF Probe and Skull Clamp for Intraoperative MR Imaging",
Neurosurgery 60:179-180, 2007.

Driscoll I, Howard SR, Stone JC, Monfils MH, Tomanek B, Brooks WM, Sutherland RJ,
"The Aging Hippocampus: A Multi-Level Analysis in the Rat",
Neuroscience 139: 1173–1185, 2006.

Wang J, Liu H, Xiang B, Li G, Gruwel M, Jackson M, Tomanek B,
Salerno TA, Deslauriers R, Tian G,
"Keeping the heart empty and beating improves preservation of hypertrophied hearts for valve surgery",
J.Thorac Cardiovasc Surg. Dec; 132(6): 1314-20, 2006.

Meng S, Qiao M, Scobie K, Tomanek B, Tuor UI,
"Evolution of magnetic resonance imaging changes associated with cerebral hypoxia-ischemia and a relatively selective white matter injury in neonatal rats",
Pediatr-Res Apr; 59(4 Pt 1): 554-9, 2006.

Wang R, Foniok T, Wamsteeker JI, Qiao M, Tomanek B, Vivianco RA, Tuor UI,
"Transient blood pressure changes affect the functional magnetic resonance imaging detection of cerebral activation",
NeuroImage May 15; 31(1): 1-11, 2006.

Majcher K; Tomanek B, Jasinski A; Foniok T; Stroman PW, Tuor UI, Kirk D; Hess G,
"Simultaneous Functional Magnetic Resonance Imaging in the Rat Spinal Cord and Brain",
Experimental Neurology 197: 458-464, 2006.

Tomanek B, Volotovskyy V, Gruwel MLH, McKenzie E, King S,
"Double-Frequency Birdcage Volume Coils for 4.7T and 7T",
Concepts in Magnetic Resonance Imaging Part B, 26(B): 16-22, 2005.

Stanwell P, Gluch L, Clark D, Tomanek B, Baker L, Giuffrè B,
Lean C, Malycha P, Mountford C,
"Specificity of Choline Metabolites For In Vivo Diagnosis of Breast Cancer Using 1H MRS at 1.5T", European Radiology 15:1037-1043, 2005.

Stroman PW, Kornelsen J, Bergman A, Krause V, Ethans K, Malisza KL, Tomanek B,
"Noninvasive assessment of the injured human spinal cord by means of functional magnetic resonance imaging",
Spinal Cord Feb; 42(2): 59-66, 2004.

Mirrashed F, Sharp JC, Krause V, Morgan J, Tomanek B,
"Pilot study of dermal and subcutaneouos fat structures by MRI in individuals who differ in gender, BMI, and cellulite grading",
Skin Research and Technology 10:161-168, 2004.

Barber P, Foniok T, Kirk D, Buchan AM, Laurent S, Boutry S, Muller RN,
Hoyte L, Tomanek B, Tuor UI,
"MR Molecular Imaging of Early Endothelial Activation in Focal Ischemia",
Ann Neurol, 56:116-120, 2004.

Gruwel MLH, Latta P, Volotovskyy V, Sramek M, Tomanek B,
"Magnetic Resonance Imaging of Seeds using Single Point Acquisition",
Journal of Agricultural and Food Chemistry 52: 4979-83, 2004.

Latta P, Gruwel MLH, Edie E, Sramek M, Tomanek B.
"Single point imaging with suppressed sound pressure levels through gradient-shape adjustment",
J.Magn Reson. Oct; 170(2): 177-83, 2004.

Qiao M, Latta P, Foniok T, Buist R, Meng S, Tomanek B and Tuor UI,
"Cerebral Blood Flow Response During Hypoxia-Ischemia and Insult Differs in Neonatal and Juvenile Rats",
MAGMA 17: 117-124, 2004.

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