Hans-Sönke Jans, PhD, FCCPM

Hans-Sönke Jan

Associate Professor, Division of Medical Physics,
Department of Oncology, University of Alberta

Senior Medical Physicist, Dept. of Medical Physics, CCI

PhD Physics: University of Heidelberg, Germany, 1993
MSc Medical Physics: University of Alberta, 2006

Fellow: Canadian College of Physicists in Medicine

Research Interests

Multimodality imaging

Image data derived from PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) scans can contribute significant information to the radiation therapy planning process, for example by defining regions of increased dose (boost) or regions where dose needs to be limited. I am evaluating the feasibility of defining such regions and their impact on radiation treatment delivery and outcome.

Quantitative imaging

Accuracy of the quantitative information contained in medical images is an important prerequisite for their utilization diagnosis and therapy. I am interested in obtaining such information from a time series of scans in both clinical an pre-clinical settings. This enables interrogating the interaction of (novel) radiopharmaceuticals with tissue, as well as their radiation dosimetry. To more exactly quantify the amount of short-lived radionuclides I am developing an ion chamber-based cross-calibration device.

Selected Publications

Ferguson F, Jans H-S, Wuest M, Riauka T, Wuest F,
"Comparison of scandium-44g with other PET radionuclides in pre-clinical PET phantom imaging",
European Journal of Nuclear Medicine and Molecular Imaging Physics, 6(1):23, Dec. 2019

Keyvanloo A, Jans H-S,
"Technical Note: Minimizing geometrical uncertainties of cylindrical well-type ionization chamber measurements: there is an optimal chamber length",
Medical Physics, 45(8): 3962-68, 2018

Jans H-S, Yang X-H, Brocks DR, Kumar P, Wuest M, Wiebe LI,
"Positron Emission Tomography (PET) and Pharmacokinetics: Classical blood sampling versus image-derived analysis of [18F]FAZA and [18F]FDG in a murine tumor bearing model",
Journal Of Pharmacy and Pharmaceutical Sciences. 21(1s):32s-47s, 2018

Jans H-S,
"Activity cross-calibration of unsealed radionuclides utilizing a portable ion chamber",
Medical Physics, 43(12): 6536-43, 2016

Morrison H, Menon G, Larocque MP, Jans H-S, Weis E, Sloboda R,
"Delivered dose uncertainty analysis at the tumour apex for ocular brachytherapy",
Medical Physics, 43(8): 4891-902, 2016

Bouvet V, Wuest M, Jans H-S, Janzen N, Genady AR, Valliant JF, Benard F, Wuest F,
"Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models",
Europ. J. Nucl. Med. Mol. Imag. Research, 6(40), May 2016

Amanie J, Jans H-S, Wuest M, Field C, Pervez N, Murtha A, Usmani N, Yee D, Danielson B, Patel S, Macewan R, Robinson D, Wilson J, Lewis D, Parliament M, McEwan AJB,
"[11C]-Choline PET/CT-guided simultaneous integrated boost to dominant intraprostatic lesions using intensity-modulated radiation therapy with helical tomotherapy technique for dose escalation",
J. Radiation Oncology 4(1): 87-93, 2015

Chapman DW, Jans H-S, Ma I, Mercer JR, Wiebe LI, Wuest M, Moore RB,
"Detecting Functional Changes with [18F]FAZA in a Renal Cell Carcinoma Mouse Model Following Sunitinib Therapy",
Europ. J. Nucl. Med. Mol. Imag. Research, 4(27), Sept. 2014

Bouvet V, Jans H-S, Wuest M, Soueidan O-M, Mercer JR , McEwan AJB, West FG, Cheeseman CI, Wuest F,
"Automated synthesis and dosimetry of 6-deoxy-6-[18F]fluoro-D-fructose (6-[18F]FDF): a radiotracer for imaging of GLUT5 in breast cancer",
American Journal of Nuclear Medicine and Molecular Imaging, 4(3): 248-59, 2014

J Amanie, H-S Jans, M Wuest, N Pervez, A Murtha, N Usmani, D Yee, R Pearcey, B Danielson, S Patel, R Macewan, C Field, D Robinson, J Wilson, D Lewis, M Parliament, AJB McEwan,
"Analysis of Intraprostatic Therapeutic Effects in Prostate Cancer Patients using [11C]-Choline PET/CT following External Beam Radiation Therapy",
Current Oncology, 20(2): 104-10, 2013

J Knight, M Wuest, F Saad, D Chapman, H-S Jans, S Lapi, B Kariuki, A Amoroso, F Wuest,
"Synthesis, characterization and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions",
Dalton Transactions, 42(33), 12005-14, 2013

A Teymurazyan, RS Sloboda, T Riauka, H-S Jans, D Robinson,
"Properties of Noise in Positron Emission Tomography Images Reconstructed with Filtered-Backprojection and Row-Action Maximum Likelihood Algorithm",
Journal of Digital Imaging, 26(3): 447-56, 2013

A Teymurazyan, T Riauka, H-S Jans, D Robinson,
"Single Seed Region Growing Algorithm in Dynamic PET Imaging (SSRG/4D-PET) for Tumor Volume Delineation in Radiotherapy Treatment Planning: Theory and Simulation",
IEEE Transactions on Nuclear Science, 59(5): 2020-32, 2012

M Wuest, P Kumar, M Wang, J Yang, H-S Jans, LI Wiebe,
"In Vitro and In Vivo Evaluation of [18F]F-GAZ, a Novel Oxygen-Mimetic Azomycin-Glucose Conjugate, for Imaging Hypoxic Tumor",
Cancer Biotherapy and Radiopharmaceuticals, 27(8): 473-80, 2012

AL Goertzen, Q Bao, M Bergeron, E Blankemeyer, S Blinder, M Cañadas, AF Chatziioannou, K Dinelle, E Elhami, H-S Jans, E Lage, R Lecomte, V Sossi, S Surti, Y-C Tai, JJ Vaquero, E Vicente, DA Williams, R Laforest,
"NEMA NU4-2008 Comparison of Preclinical PET Imaging Systems",
Journal of Nuclear Medicine, 53(8): 1300-9, 2012

M Wuest, BJ Trayner, TN Grant, HS Jans, JR Mercer, D Murray, FG West, AJB McEwan, F Wuest, CI Cheeseman,
"Radiopharmacological evaluation of 6-deoxy-6-[18F]fluoro-D-fructose as a radiotracer for PET imaging of GLUT5 in breast cancer",
Nuclear Medicine and Biology, 38(4): 461-75, 2011

RJ Paproski, M Melinda, HS Jans, K Graham, WP Gati, S McQuarrie, A McEwan, J Mercer, JD Young, CE Cass,
"Biodistribution and Uptake of 3′-Deoxy-3′-Fluorothymidine in Equilibrative Nucleoside Transporter 1 (ENT1) Knockout Mice and in an ENT1 Knockdown Tumor Model",
Journal of Nuclear Medicine, 51(9): 1447-1455, 2010.

T Stanescu, HS Jans, K Wachowicz, BG Fallone,
"Investigation of a 3D system distortion correction method for MR images",
Journal of Applied Clinical Medical Physics 11(1): 200-216, 2010.

T Stanescu, HS Jans, N Pervez, P Stavrev, BG Fallone,
"A study on the magnetic resonance imaging (MRI)-based radiation treatment planning of intracranial lesions",
Physics in Medicine and Biology 53(13): 3579-3593 JUL 2008.

S Vidakovic, HS Jans, A Alexander, RS Sloboda,
"Post-implant computed tomography-magnetic resonance prostate image registration using feature line parallelization and normalized mutual information",
Journal of Applied Clinical Medical Physics 8 (1): 21-32, 2007.

T Stanescu, HS Jans, P Stavrev, BG Fallone,
"3T MR-based treatment planning for radiotherapy of brain lesions",
Radiology and Oncology 40 (6): 125-132 JUN 2006.

HS Jans, AM Syme, S Rathee, BG Fallone,
"3D interfractional patient position verification using 2D-3D registration of orthogonal images",
Medical Physics 33 (5): 1420-1439 MAY 2006.